Mar

14

Effects of angiostatin on experimentally induced colon cancer in mice

By admin

Angiogenesis is one of the steps in tumor growth, invasion and metastasis. Antiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. Human plasminogen-derived angiostatin K1-3 is one of the most potent antiangiogenic agents currently known. However, it is unclear whether angiostatin has got protective effects on colon cancer formation. So we investigated [...]

Mar

14

By admin

The growth of solid tumors and their metastases is dependent on angiogenesis, the formation of new capillaries from pre-existing vessels. Angiogenesis is regulated by a shift in the balance of endogen angiogenic (bFGF, aFGF, VEGF vs.) and antiangiogenic factors (endostatin, angiostatin, interferon vs.) in human body. Endostatin, one of the most potent negative regulators of [...]