Effects of angiostatin on experimentally induced colon cancer in mice

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Angiogenesis is one of the steps in tumor growth, invasion and metastasis. Antiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. Human plasminogen-derived angiostatin K1-3 is one of the most potent antiangiogenic agents currently known. However, it is unclear whether angiostatin has got protective effects on colon cancer formation. So we investigated [...]

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The growth of solid tumors and their metastases is dependent on angiogenesis, the formation of new capillaries from pre-existing vessels. Angiogenesis is regulated by a shift in the balance of endogen angiogenic (bFGF, aFGF, VEGF vs.) and antiangiogenic factors (endostatin, angiostatin, interferon vs.) in human body. Endostatin, one of the most potent negative regulators of [...]